Pale Cell Squamous Cell Carcinoma in Association with Pale (Clear) Cell Acanthoma
Identifieur interne : 008231 ( Main/Exploration ); précédent : 008230; suivant : 008232Pale Cell Squamous Cell Carcinoma in Association with Pale (Clear) Cell Acanthoma
Auteurs : Liliana Mu Oz-Garcia [États-Unis] ; Aldo González-Serva [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
An 85‐year‐old woman developed a tumor on her left thigh, thought to be a squamous cell carcinoma (SCC). Microscopy revealed irregularly shaped, bulbous and deep aggregates of pale/clear cells emanating from the surface and reaching the lowermost dermis. This asymmetric mass of keratinocytes showed focal necrosis and dyskeratosis but no frank anaplasia, mitoses or infiltrative pattern. The interface with the dermis was blunt but irregularly undersurfaced. A more characteristic pale cell acanthoma (PCA) was colliding with it and consisted of a superficial, more regularly psoriasiform proliferation with thin suprapapillary plates and erosion but no necrosis. While it has been known that PCA can be unusual polypoid, large or atypical no author has proposed that some of the latter variants could represent a malignancy, more akin to verrucous carcinoma than to conventional SCC, due to the paucity of overt anaplastic features and the underestimation of pushing invasion and low cytologic atypia as defining traits of malignancy. One case of SCC in situ with PCA has been recently acknowledged but this is not what we are reporting: We propose that voluminous, misshapen, asymmetric or deep “PCAs” may be low‐grade carcinomas with pale cell differentiation and likely origin in a pre‐existing PCA.
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DOI: 10.1111/j.0303-6987.2005.320ex.x
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Microscopy revealed irregularly shaped, bulbous and deep aggregates of pale/clear cells emanating from the surface and reaching the lowermost dermis. This asymmetric mass of keratinocytes showed focal necrosis and dyskeratosis but no frank anaplasia, mitoses or infiltrative pattern. The interface with the dermis was blunt but irregularly undersurfaced. A more characteristic pale cell acanthoma (PCA) was colliding with it and consisted of a superficial, more regularly psoriasiform proliferation with thin suprapapillary plates and erosion but no necrosis. While it has been known that PCA can be unusual polypoid, large or atypical no author has proposed that some of the latter variants could represent a malignancy, more akin to verrucous carcinoma than to conventional SCC, due to the paucity of overt anaplastic features and the underestimation of pushing invasion and low cytologic atypia as defining traits of malignancy. One case of SCC in situ with PCA has been recently acknowledged but this is not what we are reporting: We propose that voluminous, misshapen, asymmetric or deep “PCAs” may be low‐grade carcinomas with pale cell differentiation and likely origin in a pre‐existing PCA.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mu Oz Arcia, Liliana" sort="Mu Oz Arcia, Liliana" uniqKey="Mu Oz Arcia L" first="Liliana" last="Mu Oz-Garcia">Liliana Mu Oz-Garcia</name></region><name sortKey="Gonzalez Erva, Aldo" sort="Gonzalez Erva, Aldo" uniqKey="Gonzalez Erva A" first="Aldo" last="González-Serva">Aldo González-Serva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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